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- Title
Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients.
- Authors
Lill, Claudia; Schneider, Sven; Pammer, Johannes; Loewe, Robert; Gedlicka, Wilhelm; Houben, Roland; Heiduschka, Gregor; Brunner, Markus; Thurnher, Dietmar
- Abstract
Background An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor. Methods Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease-free survival of patients. Results All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression ( p = .031), but expression was not significant for disease-free survival ( p = .821). The 5-year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1. Conclusions PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects
PEPTIDYLPROLYL isomerase; MERKEL cell carcinoma; CELL cycle; CELL growth; P53 protein; RETROSPECTIVE studies; IMMUNOHISTOCHEMISTRY
- Publication
Head & Neck, 2011, Vol 33, Issue 9, p1294
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21596