We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Understanding oral cancer in the genome era.
- Authors
Viet, Chi T.; Schmidt, Brian L.
- Abstract
Completion of the human genome project approximately 15 years ago was followed closely by advancements in array technology. Investigators quickly applied this new powerful tool to the genomic and proteomic study of oral squamous cell carcinoma (OSCC). Resultant publications documented chromosome, gene, mRNA, and protein alterations that characterize oral cancer. In this review, we summarize how the genomic, proteomic, and epigenetic array studies have provided insight into the process of oral carcinogenesis. We discuss the significant limitations and requirement for validation of these array studies. We also review the manner in which state-of-the-art, high-throughput approaches are being used to search for salivary and serum oral cancer biomarkers. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects
GENOMES; ORAL cancer; PROTEOMICS; SQUAMOUS cell carcinoma; HUMAN chromosomes; CARCINOGENESIS; MESSENGER RNA
- Publication
Head & Neck, 2010, Vol 32, Issue 9, p1246
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21358