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- Title
Endothelial vasoconstrictor prostanoids, vascular reactivity, and acute renal failure.
- Authors
Ruschitzka, Frank; Shaw, Sidney; Noll, Georg; Barton, Matthias; Schulz, Egbert; Müller, Gerhard A.; Lüscher, Thomas F.
- Abstract
Endothelial vasoconstrictor prostanoids, vascular reactivity, and acute renal failure. The interaction of endothelium-derived vasoconstrictor prostaglandins, the angiotensins (Ang), and the sympathetic nervous system in acute renal failure still remains to be determined. In this study, acute renal failure (ARF) was induced in male Wistar Kyoto rats ( N = 7) in a 2K/2C model of 30-minute clamping. Contractions to Ang I and II and norepinephrine (NE) were studied in isolated aortic and renal artery rings 24 hours after clamp release. Sham-operated animals served as controls ( N = 7). In ARF, contractions to NE were increased in the aorta and even further enhanced in the renal artery ( P < 0.05 to 0.001), whereas contractions to Ang I and II were blunted ( P < 0.05). Contractions were inhibited by SQ 30741, a thromboxane A 2 (TXA 2 )/prostaglandin H 2 (PGH 2 ) receptor antagonist. We conclude that ARF is characterized by abnormal vascular reactivity both in the renal as well as the systemic vasculature that is in part mediated by endothelium-derived vasoconstrictor prostaglandins.
- Subjects
VASOCONSTRICTORS; PROSTANOIDS; ACUTE kidney failure; PROSTAGLANDINS; ANGIOTENSINS
- Publication
Kidney International, 1998, Vol 54, pS199
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.1998.06746.x