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- Title
Postoperative radiotherapy dose requirement in standard combined-modality practice for head and neck squamous cell carcinoma: Analysis of salient surgical and radiotherapy parameters in 2 cohorts.
- Authors
Mohanti, Bidhu K.; Thakar, Alok; Kaur, Jaspreet; Bahadur, Sudhir; Malik, Monica; Gandhi, Ajeet K.; Bhasker, Suman; Sharma, Atul
- Abstract
Background This study compared 2 sequential cohorts to identify the postoperative radiotherapy (PORT) dose requirement for head and neck squamous cell carcinoma (HNSCC). Methods Two distinct PORT dose regimens were prescribed over 11 years; group 1 received 56 Gy or less, and group 2 received 60 Gy or more. The 2D and 3D techniques were used. Results Two sequential cohorts consisted of 478 patients, with mean and median follow-up for group 1 and 2 as: 37.0 versus 28.5 months and 13.8 versus 13.1 months, respectively. Grades 3-4 mucosal toxicities (11.4% vs 28.3%), hospitalization (3.2% vs 17.4%), and nasogastric feeding (11.9% vs 29.7%) were higher in group 2. The 2-year disease-free survival (DFS) was higher with PORT >60 Gy for the following factors: age ≤ 50 years ( P = .041); ≥ 4 positive nodes ( P = .029); and overall treatment time (OTT) ≥ 100 days ( P = .042). Conclusion Except for the benefit of doses >60 Gy for limited parameters, a lower PORT dose did not compromise the results and can potentially reduce the morbidities and healthcare costs.
- Subjects
POSTOPERATIVE care; CANCER radiotherapy; HEAD &; neck cancer; SQUAMOUS cell carcinoma; CANCER treatment
- Publication
Head & Neck, 2017, Vol 39, Issue 9, p1788
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24836