We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
MMP-8 -799 C> T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese.
- Authors
Chou, Yu-Hsiang; Ho, Ya-Ping; Lin, Ying-Chu; Hu, Kai-Fang; Yang, Yi-Hsin; Ho, Kun-Yen; Wu, Yi-Min; Hsi, Edward; Tsai, Chi-Cheng
- Abstract
Aim Matrix metalloproteinase ( MMP)-8 is a protease that degrades numerous extracellular molecules and has been implicated in the pathogenesis of periodontitis. Polymorphism in the MMP-8 could affect the susceptibility to disease. Our aim was to evaluate the association between periodontitis and MMP-8 -799 C> T polymorphism. Material and methods Genomic DNA was obtained from 361 chronic periodontitis patients ( CP), 96 aggressive periodontitis patients ( AgP), and 106 periodontally healthy controls ( HC). MMP-8 -799 C> T polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism ( PCR- RFLP). Results The frequencies of genotypes in diseased groups were similar but were significantly different from those in the HC. Multivariate logistic regression analysis with adjustment for age, gender and smoking indicated that increased risks of AgP and CP were associated with the -799 T allele (in AgP, adjusted OR = 1.99, p = 0.04; in CP, adjusted OR = 1.87, p = 0.007). To avoid the confounded effect of smoking on MMP-8 polymorphism to periodontitis, the analysis was conducted on non-smokers and the associations were significant. Conclusions These results suggested that non-smoking Taiwanese with the MMP-8 -799 T allele were associated with the risks of both CP and AgP. Further studies in other ethnic populations are necessary.
- Subjects
TAIWAN; CHRONIC disease risk factors; PERIODONTITIS; DNA analysis; AGGRESSIVE periodontitis; ANALYSIS of variance; CHI-squared test; CONFIDENCE intervals; GENES; GENETIC polymorphisms; POLYMERASE chain reaction; SMOKING; MATHEMATICAL variables; MULTIPLE regression analysis; STATISTICAL significance; RELATIVE medical risk; HUMAN research subjects; CASE-control method; PATIENT selection; DATA analysis software; DISEASE risk factors
- Publication
Journal of Clinical Periodontology, 2011, Vol 38, Issue 12, p1078
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/j.1600-051X.2011.01798.x