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- Title
DIFFUSE HEPATIC CALCIFICATION - A MARKER OF HYPOPARATHYROIDISM IN BETA THALASSEMIA DUE TO IRON OVERLOAD.
- Authors
Khaladkar, Sanjay M.; Chouhan, Dinesh; Doshi, Foram
- Abstract
Iron overload can occur in beta thalassemia. The iron overload can damage liver, heart and endocrine organs. Non-endocrine complications due to iron overload are liver fibrosis and cirrhosis, skeletal manifestations and dilated cardiomyopathy. Endocrine manifestations are pituitary insufficiency, failure of sexual maturation, delayed puberty and hypogonadism, diabetes mellitus and glucose intolerance due to pancreatic insufficiency, dyslipidaemia, hypoadrenalism, hypothyroidism and hypoparathyroidism. Hypoparathyroidism is seen upto 6.7 % of thalassemia major (TM) patients and is the most prevalent endocrine complications of thalassemia major. Diffuse hepatic calcification and calcification in the brain occur in beta thalassemia due to hypoparathyroidism. Isolated intracerebral calcification due to hypoparathyroidism has been reported previously. Isolated hepatic calcification is infrequent with only one reported case in thalassemia. We report the first case of an 18- year old beta-thalassemia major patient, with hypoparathyroidism with extensive diffuse hepatic calcification and brain calcification.
- Subjects
BETA-Thalassemia; HYPOPARATHYROIDISM; CALCIFICATION; LIVER diseases; BRAIN calcification
- Publication
Pakistan Journal of Radiology, 2018, Vol 28, Issue 4, p317
- ISSN
1607-2006
- Publication type
Article