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- Title
Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model.
- Authors
de Mello, Aline Haas; Schraiber, Rosiane de Bona; Goldim, Mariana Pereira de Souza; Mathias, Khiany; Mendes, Carolini; Corrêa, Maria Eduarda Anastácio Borges; Gomes, Maria Luiza; Silveira, Paulo Cesar Lock; Schuck, Patrícia Fernanda; Petronilho, Fabricia; Rezin, Gislaine Tezza
- Abstract
This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)−1·day−1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.
- Subjects
OMEGA-3 fatty acids; UNSATURATED fatty acids; FISH oils; WESTERN diet; FAT; KREBS cycle; LOW-fat diet; HIGH-fat diet
- Publication
Biochemistry & Cell Biology, 2019, Vol 97, Issue 6, p693
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/bcb-2018-0361