In this work, the synthesis of 1,3,4-oxadiazole derivatives using triphenylphosphine dibromide/triethylamine (Ph3P/Br2/Et3N), 1,2-bis(diphenylphosphaneyl)ethane/2Br2/Et3N, and nano-silica-anchored PPh2/Br2/Et3N systems is described. The method allows the preparation of 1,3,4-oxadiazoles with a broad substrate scope from easily accessible materials.