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- Title
Management of Persistent SARS-CoV-2 Infection in Patients with Follicular Lymphoma.
- Authors
Martínez-Barranco, Pilar; García-Roa, María; Trelles-Martínez, Roberto; Arribalzaga, Karmele; Velasco, María; Guijarro, Carlos; Marcos, Javier; Campelo, Carolina; Acedo-Sanz, Juan Manuel; Villalón, Lucía; Ricard, Pilar; García-Bueno, María José; Pérez-Fernández, Elia; Rodríguez-Caravaca, Gil; Peñalver, Francisco-Javier
- Abstract
Introduction: There is no consensus on the management of the coronavirus disease (COVID-19) in patients with secondary immunosuppression due to either an underlying hematological disease or to the effects of immunochemotherapy (ICT). Some of them may present persistent infection with multiple relapses of COVID-19, requiring several admissions. This study evaluated the clinical characteristics and outcomes after treatment of 5 patients with follicular lymphoma (FL), previously treated with ICT, who developed several episodes of COVID-19. Methods: We analyzed the clinical evolution and response to treatment with antiviral agent, steroids, and convalescent plasma in 5 patients with FL and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persistent infection. Reverse transcriptase polymerase chain reaction tests and peripheral blood immunophenotype were performed for all patients. Results: All patients required hospitalization due to pneumonia with severity criteria and were re-admitted after a median of 22 days (13–42) from the previous discharge. They all showed B-cell depletion by immunophenotyping, and no traces of immunoglobulin antibodies against SARS-CoV-2 were detected in any of the cases. The survival rate was 80%. Conclusion: The combination therapy evidenced clinical benefits, demonstrating its capacity to control infection in immunosuppressed FL patients treated with ICT.
- Subjects
SARS-CoV-2; FOLLICULAR lymphoma; REVERSE transcriptase polymerase chain reaction; CORONAVIRUS diseases; CONVALESCENT plasma
- Publication
Acta Haematologica, 2022, Vol 145, Issue 4, p384
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000521121