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- Title
CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells.
- Authors
Piercy, Jenny; Petrova, Svetla; Tchilian, Elma Z.; Beverley, Peter C. L.
- Abstract
CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45–/– bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll-like receptor (TLR)3 and TLR9. Nuclear factor-κB activation, an important downstream consequence of TLR3 and TLR9 signalling, is also increased in CD45–/– BMDC. BMDC of CD45–/– mice also produce more TNF and IL-6 following stimulation with the cytokines TNF and interferon-α. These results show that TLR signalling is increased in CD45–/– dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells.
- Subjects
CELL receptors; DENDRITIC cells; BONE marrow; TUMOR necrosis factors; INTERLEUKIN-6; CYTOKINES
- Publication
Immunology, 2006, Vol 118, Issue 2, p250
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2006.02363.x