We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Subventricular Zone Stem Cells Are Heterogeneous with Respect to Their Embryonic Origins and Neurogenic Fates in the Adult Olfactory Bulb.
- Authors
Young, Kaylene M.; Fogarty, Matthew; Kessaris, Nicoletta; Richardson, William D.
- Abstract
We determined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. We found that all parts of the telencephalic neuroepithelium, including the medial ganglionic eminence and lateral ganglionic eminence (LGE) and the cerebral cortex, contribute multipotent, self-renewing stem cells to the adult SVZ. Descendants of the embryonic LGE and cortex settle in ventral and dorsal aspects of the dorsolateral SVZ, respectively. Both populations contribute new (5-bromo-2'- deoxyuridine-labeled) tyrosine hydroxylase- and calretinin-positive interneurons to the adult olfactory bulb. However, calbindin-positive interneurons in the olfactory glomeruli were generated exclusively by LGE-derived stem cells. Thus, different SVZ stem cells have different embryonic origins, colonize different parts of the SVZ, and generate different neuronal progeny, suggesting that some aspects of embryonic patterning are preserved in the adult SVZ. This could have important implications for the design of endogenous stem cell-based therapies in the future.
- Subjects
NEURAL stem cells; OLFACTORY nerve; TRANSGENIC mice; TELENCEPHALON; CEREBRAL cortex; INTERNEURONS
- Publication
Journal of Neuroscience, 2007, Vol 27, Issue 31, p8286
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0476-07.2007