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The Glycine Transporter Type 1 Inhibitor N-[3-(4'-Fluorophenyl)-3-(4'-Phenylphenoxy) Propyl] Sarcosine Potentiates NMDA Receptor-Mediated Responses In Vivo and Produces an Antipsychotic Profile in...
Published in:
Journal of Neuroscience, 2003, v. 23, n. 20, p. 7586, doi. 10.1523/JNEUROSCI.23-20-07586.2003
By:
- Kinney, Gene G.;
- Sur, Cyrille;
- Burno, Maryann;
- Mallorga, Pierre J.;
- Williams, Jacinta B.;
- Figueroa, David J.;
- Wittman, Marion;
- Lemaire, Wei;
- Conn, P. Jeffrey
Publication type:
Article
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists.
Published in:
Cell Biochemistry & Biophysics, 2009, v. 55, n. 2, p. 81, doi. 10.1007/s12013-009-9057-4
By:
- Victor Uebele;
- Cindy Nuss;
- Steven Fox;
- Susan Garson;
- Razvan Cristescu;
- Scott Doran;
- Richard Kraus;
- Vincent Santarelli;
- Yuxing Li;
- James Barrow;
- Zhi-Qiang Yang;
- Kelly-Ann Schlegel;
- Kenneth Rittle;
- Thomas Reger;
- Rodney Bednar;
- Wei Lemaire;
- Faith Mullen;
- Jeanine Ballard;
- Cuyue Tang;
- Ge Dai
Publication type:
Article
Difference in mGluR5 Interaction between Positive Allosteric Modulators from Two Structural Classes.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 1003, n. 1, p. 481, doi. 10.1196/annals.1300.059
By:
- WILLIAMS, DAVID L.;
- O'BRIEN, JULIE A.;
- LEMAIRE, WEI;
- CHEN, TSING-BAU;
- CHANG, RAYMOND S. L.;
- JACOBSON, MARLENE A.;
- HA, SOOKHEE N.;
- WISNOSKI, DAVID D.;
- LINDSLEY, CRAIG W.;
- SUR, CYRILLE;
- DUGGAN, MARK E.;
- PETTIBONE, DOUGLAS J.;
- CONN, P. JEFFREY
Publication type:
Article
Discovery of 5′′-Chloro- N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia.
Published in:
ChemMedChem, 2014, v. 9, n. 2, p. 311, doi. 10.1002/cmdc.201300447
By:
- Roecker, Anthony J.;
- Mercer, Swati P.;
- Schreier, John D.;
- Cox, Christopher D.;
- Fraley, Mark E.;
- Steen, Justin T.;
- Lemaire, Wei;
- Bruno, Joseph G.;
- Harrell, C. Meacham;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Fox, Steven V.;
- Stevens, Joanne;
- Tannenbaum, Pamela L.;
- Prueksaritanont, Thomayant;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Stellabott, Joyce;
- Hartman, George D.;
- Young, Steven D.
Publication type:
Article
Cover Picture: Discovery of 5′′-Chloro- N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia (ChemMedChem 2/2014)
Published in:
ChemMedChem, 2014, v. 9, n. 2, p. 241, doi. 10.1002/cmdc.201490000
By:
- Roecker, Anthony J.;
- Mercer, Swati P.;
- Schreier, John D.;
- Cox, Christopher D.;
- Fraley, Mark E.;
- Steen, Justin T.;
- Lemaire, Wei;
- Bruno, Joseph G.;
- Harrell, C. Meacham;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Fox, Steven V.;
- Stevens, Joanne;
- Tannenbaum, Pamela L.;
- Prueksaritanont, Thomayant;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Stellabott, Joyce;
- Hartman, George D.;
- Young, Steven D.
Publication type:
Article
Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties.
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 415, doi. 10.1002/cmdc.201200025
By:
- Coleman, Paul J.;
- Schreier, John D.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Whitman, David B.;
- Bogusky, Michael J.;
- McGaughey, Georgia B.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Doran, Scott M.;
- Fox, Steven V.;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Harrell, C. Meacham;
- Reiss, Duane R.;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Prueksaritanont, Thomayant;
- Stevens, Joanne;
- Tannenbaum, Pamela L.
Publication type:
Article
Cover Picture: Discovery of [(2 R,5 R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties (ChemMedChem 3/2012).
Published in:
ChemMedChem, 2012, v. 7, n. 3, p. 337, doi. 10.1002/cmdc.201290006
By:
- Coleman, Paul J.;
- Schreier, John D.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Whitman, David B.;
- Bogusky, Michael J.;
- McGaughey, Georgia B.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Doran, Scott M.;
- Fox, Steven V.;
- Garson, Susan L.;
- Gotter, Anthony L.;
- Harrell, C. Meacham;
- Reiss, Duane R.;
- Cabalu, Tamara D.;
- Cui, Donghui;
- Prueksaritanont, Thomayant;
- Stevens, Joanne;
- Tannenbaum, Pamela L.
Publication type:
Article
Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N, N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats.
Published in:
ChemMedChem, 2009, v. 4, n. 7, p. 1069, doi. 10.1002/cmdc.200900069
By:
- Whitman, David B.;
- Cox, Christopher D.;
- Breslin, Michael J.;
- Brashear, Karen M.;
- Schreier, John D.;
- Bogusky, Michael J.;
- Bednar, Rodney A.;
- Lemaire, Wei;
- Bruno, Joseph G.;
- Hartman, George D.;
- Reiss, Duane R.;
- Harrell, C. Meacham;
- Kraus, Richard L.;
- Li, Yuxing;
- Garson, Susan L.;
- Doran, Scott M.;
- Prueksaritanont, Thomayant;
- Li, Chunze;
- Winrow, Christopher J.;
- Koblan, Kenneth S.
Publication type:
Article
Design, Synthesis, and In Vivo Efficacy of Glycine Transporter-1 (GlyT1) Inhibitors Derived from a Series of [4-Phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl Benzamides.
Published in:
ChemMedChem, 2006, v. 1, n. 8, p. 807, doi. 10.1002/cmdc.200600097
By:
- Lindsley, Craig W.;
- Zhao, Zhijian;
- Leister, William H.;
- O'Brien, Julie;
- Lemaire, Wei;
- Williams, David L.;
- Chen, Tsing-Bau;
- Chang, Raymond S. L.;
- Burno, Maryann;
- Jacobson, Marlene A.;
- Sur, Cyrille;
- Kinney, Gene G.;
- Pettibone, Douglas J.;
- Tiller, Philip R.;
- Smith, Sheri;
- Tsou, Nancy N.;
- Duggan, Mark E.;
- Conn, P. Jeffrey;
- Hartman, George D.
Publication type:
Article

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