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- Title
GUILLAIN-BARRE SYNDROME FOLLOWING VACCINATION IN THE NATIONAL INFLUENZA IMMUNIZATION PROGRAM, UNITED STATES, 1976–19771.
- Authors
SCHONBERGER, LAWRENCE B.; BREGMAN, DENNIS J.; SULLIVAN-BOLYAI, JOHN Z; KEENLYSIDE, RICHARD A.; ZIEGLER, DONALD W.; RETAILLIAU, HENRY F.; EDDINS, DONALD L; BRYAN, JOHN A.
- Abstract
Because of an increase in the number of reports of Guillain-Barre syndrome (GBS) following A/New Jersey influenza vaccination, the National Influenza Immunization Program was suspended December 16, 1976 and nationwide surveillance for GBS was begun. This surveillance uncovered a total of 1098 patients with onset of GBS from October 1, 1976, to January 31, 1977, from all 50 states, District of Columbia, and Puerto Rico. A total of 532 patients had recently received an A/New Jersey influenza vaccination prior to their onset of GBS (vaccinated cases), and 15 patients received a vaccination after their onset of GBS. Five hundred forty-three patients had not been recently vaccinated with A/New Jersey influenza vaccine and the vaccination status for 8 was unknown. Epidemiologic evidence indicated that many cases of GBS were related to vaccination. When compared to the unvaccinated population, the vaccinated population had a significantly elevated attack rate in every adult age group. The estimated attributable risk of vaccine-related GBS in the adult population was just under one case per 100,000 vaccinations. The period of increased risk was concentrated primarily within the 5-week period after vaccination, although it lasted for approximately 9 or 10 weeks.
- Publication
American Journal of Epidemiology, 1979, Vol 110, Issue 2, p105
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/oxfordjournals.aje.a112795