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- Title
Patients With Peripheral Arterial Disease With Exaggerated Pressor Response Have Greater Ambulatory Dysfunction Than Patients With Lower Pressor Response.
- Authors
Kim, Danielle Jin-Kwang; Montgomery, Polly S.; Wang, Ming; Shen, Biyi; Kuroki, Marcos; Gardner, Andrew W.
- Abstract
We determined whether patients with peripheral arterial disease (PAD) who have either an exaggerated or a negative pressor response during treadmill walking have shorter peak walking time (PWT) and claudication onset time (COT) than patients with a normal pressor response, independent of comorbid conditions. A total of 249 patients were categorized to 1 of 3 groups based on systolic blood pressure (SBP) responses at 2 minutes of treadmill walking (speed = 2 mph, grade = 0%): group 1 (negative pressor response, SBP < 0 mm Hg), group 2 (normal pressor response, SBP 18 mm Hg), and group 3 (exaggerated pressor response, SBP > 18 mm Hg). After adjusting for comorbid conditions, group 3 (exaggerated) had significantly reduced COT (P =.011) and PWT (P =.002) compared to group 2 (normal), while group 1 (negative) and group 2 (normal) were not different. Patients with symptomatic PAD with an increase in SBP > 18 mm Hg after 2 minutes of treadmill walking experience claudication earlier and thus have greater ambulatory dysfunction, compared to patients with PAD with a normal pressor response, whereas patients with PAD with negative pressor response had a similar walking performance. The implication is that the magnitude of pressor response to only 2 minutes of treadmill walking can partially explain the degree of ambulatory dysfunction in patients with PAD.
- Subjects
AMBULATORY blood pressure monitoring; BLOOD pressure; CARDIOPULMONARY system; COMPARATIVE studies; EXERCISE tests; INTERMITTENT claudication; HEALTH outcome assessment; PERIPHERAL vascular diseases; TIME; WALKING; COMORBIDITY; TREADMILLS; DESCRIPTIVE statistics; DISEASE complications
- Publication
Angiology, 2020, Vol 71, Issue 8, p747
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319720925970