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- Title
Effects of UV/H 2 O 2 Degradation on the Physicochemical and Antibacterial Properties of Fucoidan.
- Authors
He, Zhicheng; Zhu, Biyang; Deng, Lijuan; You, Lijun
- Abstract
The applications of fucoidan in the food industry were limited due to its high molecular weight and low solubility. Moderate degradation was required to depolymerize fucoidan. A few studies have reported that fucoidan has potential antibacterial activity, but its antibacterial mechanism needs further investigation. In this study, the degraded fucoidans were obtained after ultraviolet/hydrogen peroxide treatment (UV/H2O2) at different times. Their physicochemical properties and antibacterial activities against Staphylococcus aureus and Escherichia coli were investigated. The results showed that the average molecular weights of degraded fucoidans were significantly decreased (up to 22.04 times). They were mainly composed of fucose, galactose, and some glucuronic acid. Fucoidan degraded for 90 min (DFuc-90) showed the strongest antibacterial activities against Staphylococcus aureus and Escherichia coli, with inhibition zones of 27.70 + 0.84 mm and 9.25 + 0.61 mm, respectively. The minimum inhibitory concentrations (MIC) were 8 mg/mL and 4 mg/mL, respectively. DFuc-90 could inhibit the bacteria by damaging the cell wall, accumulating intracellular reactive oxygen species, reducing adenosine triphosphate synthesis, and inhibiting bacterial metabolic activity. Therefore, UV/H2O2 treatment could effectively degrade fucoidan and enhance its antibacterial activity.
- Subjects
BACTERIAL cell walls; ADENOSINE triphosphate; REACTIVE oxygen species; ANTIBACTERIAL agents; GLUCURONIC acid; STAPHYLOCOCCUS aureus
- Publication
Marine Drugs, 2024, Vol 22, Issue 5, p209
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22050209