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- Title
Nephrotic Syndrome and Posterior Reversible Encephalopathy Syndrome as Clinical Presentations of Gemcitabine-Induced Thrombotic Micro-Angiopathy.
- Authors
Jha, Vijoy Kumar; Akal, Ramanjit Singh; Mahapatra, Debasish; Sharma, Alok; Singh, Bhanu Pratap; Arora, Rahil
- Abstract
Gemcitabine-induced thrombotic micro-angiopathy (GiTMA) is a very rare pathology of micro-vascular occlusion with a poor prognosis. In this case report, we present a young male with pancreatic carcinoma who received gemcitabine as adjuvant chemotherapy and developed thrombotic micro-angiopathy (TMA) manifesting as nephrotic syndrome with renal dysfunction and posterior reversible encephalopathy syndrome (PRES). The case was successfully managed with discontinuation of the drug and conservative management. The pathogenesis of GiTMA might be direct endothelial dysfunction with consequent activation of the clotting system. The role of plasma exchanges and monoclonal antibodies is unclear in drug-induced TMA.
- Subjects
THERAPEUTIC use of antineoplastic agents; BIOPSY; PLEURAL effusions; HYPERBILIRUBINEMIA; CREATININE; BRAIN; BILE duct diseases; CHEST X rays; MAGNETIC resonance imaging; NEPHROTIC syndrome; PANCREATIC tumors; GEMCITABINE; THROMBOTIC thrombocytopenic purpura; SEIZURES (Medicine); POSTERIOR leukoencephalopathy syndrome; ANTICONVULSANTS; DISEASE complications
- Publication
Indian Journal of Nephrology, 2024, Vol 34, Issue 1, p74
- ISSN
0971-4065
- Publication type
Article
- DOI
10.4103/ijn.ijn_277_22