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- Title
Role of Cinacalcet in Treating Cardiac Dysfunction Secondary to Hyperparathyroidism: A Case Series.
- Authors
Ohri, Alpana; Goyal, Samridhi; Udani, Amish; Gupta, Madhukar
- Abstract
Cardiovascular disease is a leading cause of death in children with chronic kidney disease (CKD). A strong correlation exists between disturbed calcium--phosphate metabolism and cardiac dysfunction. Studies with use of cinacalcet in CKD are few and limited to older children and adults and in improving growth and bone deformities. We present three children with CKD on CAPD with cardiac dysfunction with refractory hyperparathyroidism. Patients were initiated on lowest adult weight-adjusted dose of 0.2 mg/kg/day. Dose was titrated every 30 days to achieve decline in iPTH to a goal of 200-300 pg/ml. Serum calcium, phosphorus and iPTH levels were checked monthly. Complications of therapy related to cinacalcet monitored. Monthly echocardiography done to monitor cardiac dysfunction. None of them experienced significant adverse effects of cinacalcet therapy.
- Subjects
TREATMENT of chronic kidney failure; CHRONIC kidney failure complications; POLYCYCLIC aromatic hydrocarbons; CONTINUOUS ambulatory peritoneal dialysis; CARDIOVASCULAR diseases; HYPERPARATHYROIDISM; TREATMENT effectiveness; ELECTROCARDIOGRAPHY; DISEASE complications; EVALUATION; CHILDREN
- Publication
Indian Journal of Nephrology, 2022, Vol 32, Issue 2, p172
- ISSN
0971-4065
- Publication type
Article
- DOI
10.4103/ijn.IJN_262_20