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- Title
Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases.
- Authors
Blažević, Tina; Heiss, Elke H.; Atanasov, Atanas G.; Breuss, Johannes M.; Dirsch, Verena M.; Uhrin, Pavel
- Abstract
Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine formulation. The encouraging clinical results from the 1980s obtained in chronic myelocytic leukemia patients treated with indirubin stimulated numerous studies on this compound. These investigations explored the use of indirubin in different types of cancer and reported the synthesis of novel derivatives with improved chemical and pharmacokinetic properties. In this paper, we review the impressive progress that has been made in elucidating the mechanistic understanding of how indirubin and its derivatives affect physiological and pathophysiological processes, mainly by inhibition of cell proliferation and induction of cell death. Furthermore, we survey the therapeutic use of these compounds in combating proliferative diseases such as cancer, restenosis, and psoriasis.
- Subjects
TUMOR prevention; CORONARY restenosis prevention; ANIMAL experimentation; APOPTOSIS; BIOPHYSICS; CELL death; CELL differentiation; CLINICAL medicine research; HERBAL medicine; RESEARCH methodology; CHINESE medicine; MOLECULAR structure; PSORIASIS; TUMORS; PATHOLOGIC neovascularization; PHYTOCHEMICALS; IN vitro studies; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, Vol 2015, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2015/654098