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- Title
Changes in the renin angiotensin system duringthe development of colorectal cancer livermetastases.
- Authors
Neo, Jaclyn H.; Ager, Eleanor I.; Angus, Peter W.; Jin Zhu; Herath, Chandana B.; Christophi, Christopher
- Abstract
Background: It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear. Methods: The methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas. Results: Intensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi- 1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005). Conclusions: These findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients.
- Subjects
CANCER patients; METASTASIS; COLON cancer; LIVER cancer; ADNEXA uteri
- Publication
BMC Cancer, 2010, Vol 10, p134
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/1471-2407-10-134