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- Title
Toward Personalized Cell Therapies by Using Stem Cells: Seven Relevant Topics for Safety and Success in Stem Cell Therapy.
- Authors
de Sá Silva, Fernando; Nascimento Almeida, Paula; Paes Rettore, João Vitor; Pereira Maranduba, Claudinéia; de Souza, Camila Maurmann; Torres de Souza, Gustavo; de Souza Salomão Zanette, Rafaella; Harumi Miyagi, Sueli Patricia; de Oliveira Santos, Marcelo; Martins Marques, Márcia; da Costa Maranduba, Carlos Magno
- Abstract
Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. In fact, stem cells can be considered revolutionary in the field of medicine, especially in the treatment of a wide range of human diseases. However, caution is needed in the clinical application of such cells and this is an issue that demands more studies. This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. Particularly, the following aspects of stem cell biology will be presented: methods for stem cells culture, teratogenic or tumorigenic potential, cellular dose, proliferation, senescence, karyotyping, and immunosuppressive activity.
- Subjects
CELL culture; HEMATOPOIETIC stem cells; KARYOTYPES; RESEARCH funding; TERATOGENIC agents; SYSTEMATIC reviews; STEM cell research
- Publication
Journal of Biomedicine & Biotechnology, 2012, Vol 2012, p1
- ISSN
1110-7243
- Publication type
Article
- DOI
10.1155/2012/758102