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- Title
An iron-based T<sub>1</sub> contrast agent made of iron-phosphate complexes: In vitro and in vivo studies.
- Authors
Elisenda Rodríguez; Anna Roig; Elies Molins; Nataliya Nedelko; Anna Ślawska-Waniewska; Silvio Aime; Carles Arús; Miquel Cabañas; Coral Sanfeliu; Sebastián Cerdán; Maria García-Martín
- Abstract
Abstract??A new iron-basedT1contrast agent consisting of a complex of iron ions coordinated to phosphate and amine ligands (Fe(phos)in short) has been characterized by spectroscopic and magnetic measurements. NMR relaxation studies showedr1values to be dependent on the phosphate salt concentration, K2HPO4, present in the medium.r1reaches a maximum value of 2.5?mM?1?s?1for measurements carried out at 7?T and 298?K.31P MRS, M?ssbauer spectroscopy and magnetic measurements of Fe(phos)solutions suggest paramagnetic Fe3+ions present in the studied iron?phosphate complex. In vitro and in vivo toxicity experiments with C6 cells and CD1 mice, respectively, demonstrated lack of toxicity for Fe(phos)at the highest dose tested in the MRI experiments (12?mM iron for C6 cells and 0.32?mmol iron/kg for mice). Finally,T1weighted images of brain tumours in mice have shown positive contrast enhancement of Fe(phos)for tumour afflicted regions in the brain.
- Subjects
BRAIN; IONS; IRON ions; METAL ions
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2007, Vol 20, Issue 1, p27
- ISSN
0968-5243
- Publication type
Article