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- Title
Hydrothermal Synthesis and Functionalization of Iron Oxide Nanoparticles for MR Imaging Applications.
- Authors
Li, Jingchao; Shi, Xiangyang; Shen, Mingwu
- Abstract
This article reports the recent advances in hydrothermally synthesized iron oxide nanoparticles (Fe3O4 NPs) used for magnetic resonance (MR) imaging applications. The hydrothermally synthesized Fe3O4 NPs have a controllable size, narrow size distribution, and tunable magnetic properties. For biomedical imaging applications, the surface-functionalized Fe3O4 NPs with good water dispersibility, colloid stability, and relatively high r2 relaxivity can be synthesized using modified hydrothermal routes, and can be further surface functionalized with targeting ligands, enabling effective tumor MR imaging with high specificity via receptor-mediated active targeting pathway. What is more, the hydrothermal route can also be used to synthesize Fe3O4@Au composite nanoparticles (CNPs) for dual-mode MR and computed tomography (CT) imaging applications. Some of the key developments in this area of research will be introduced in detail.
- Subjects
IRON oxide nanoparticles; MAGNETIC resonance imaging; DIAGNOSTIC imaging; CANCER prevention; COMPUTED tomography
- Publication
Particle & Particle Systems Characterization, 2014, Vol 31, Issue 12, p1223
- ISSN
0934-0866
- Publication type
Article
- DOI
10.1002/ppsc.201400087