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- Title
Increased premenstrual dosing of nefazodone relieves premenstrual magnification of depression.
- Authors
Miller, Merry N.; Miller, Barney E.; Chinouth, Rick; Coyle, Brent R.; Brown, George R.
- Abstract
We report on 3 subjects with premenstrual magnification of major depression (PMMD) treated with nefazodone who benefited from a supplement of additional nefazodone premenstrually. During the 6-month study, subjects were given supplements of either additional nefazodone or placebo prior to the expected onset of menses (double-blind crossover design). Symptoms were assessed during the late luteal and follicular phases. All subjects showed significant improvement for the months in which they received nefazodone supplements, but not when given placebo. Premenstrual dose increase is a clinically promising intervention for women who experience PMMD.
- Subjects
ANTIDEPRESSANTS; MENTAL depression; THERAPEUTICS; PREMENSTRUAL syndrome; PSYCHIATRIC drugs; DEPRESSION in women; COMPARATIVE studies; DOSE-effect relationship in pharmacology; HETEROCYCLIC compounds; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; TREATMENT effectiveness; SEVERITY of illness index; SECOND-generation antidepressants
- Publication
Depression & Anxiety (1091-4269), 2002, Vol 15, Issue 1, p48
- ISSN
1091-4269
- Publication type
journal article
- DOI
10.1002/da.1086