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- Title
Skeletal Editing: Interconversion of Arenes and Heteroarenes.
- Authors
Joynson, Ben W.; Ball, Liam T.
- Abstract
Skeletal editing involves making specific point‐changes to the core of a molecule through the selective insertion, deletion or exchange of atoms. It thus represents a potentially powerful strategy for the step‐economic modification of complex substrates and is a perfect complement to methods such as C−H functionalization that target the molecular periphery. Given their ubiquity in biologically active compounds, the ability to perform skeletal editing on – and therefore interconvert between – aromatic heterocycles is especially valuable. This review summarizes both recent and key historical examples of skeletal editing as applied to interconversion of aromatic rings; we anticipate that it will serve to highlight not only the innovative and enabling nature of current skeletal editing methods, but also the tremendous opportunities that still exist in the field.
- Subjects
HETEROARENES; BIOACTIVE compounds; DRUG discovery
- Publication
Helvetica Chimica Acta, 2023, Vol 106, Issue 3, p1
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.202200182