We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biomimetic Model of Coenzyme B12: Aquabis(ethane-1,2-diamine-κN,κN′)ethylcobalt(III) – Its Kinetic and Binding Studies with Imidazoles and Amino Acids and Interactions with CT DNA.
- Authors
Ponuganti Pallavi; Penumaka Nagababu; Sirasani Satyanarayana
- Abstract
Pseudo-first-order reaction kinetics and binding studies of trans-[Co(en)2(Et)H2O] complex with 1H-imidazole, substituted 1H-imidazoles, histidine, histamine, glycine and glycine ethyl ester were investigated by means of spectrophotometric techniques. Equilibrium constants were determined as a function of pH at 25°. Binding and kinetic studies were correlated to basicity and steric hindrance. From the equilibrium data, it was found that the entering nucleophile is participating in the transition state, an Id mechanism is proposed. The effect of the incoming ligands on the complex was studied by molecular mechanics. The interaction of trans-[Co(en)2(Et)H2O] with CT DNA was studied spectrophotometrically.
- Subjects
COENZYMES; CHEMICAL kinetics; AMINO acids; DNA
- Publication
Helvetica Chimica Acta, 2007, Vol 90, Issue 3, p627
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.200790065