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- Title
A Novel Concept for Combinatorial Chemistry in Solution: Synthesis of Highly Substituted Pyrrolidines by Multicomponent Domino Reactions.
- Authors
Tietze, Lutz F.; Evers, Holger; Töpken, Enno
- Abstract
The multicomponent domino Knoevenagel hetero- Diels Alder hydrogenation process of N-[(benzyloxy)carbonyl(Cbz)-protected amino aldehydes with N, N-dimethylbarbituric acid and the trimethylsilyl enol ethers 1- 3 leads to the formation of the substituted pyrrolidines 12- 15. Under the same conditions, reaction of the trimethylsilyl enol ether 4, obtained from acetophenone, gave the primary amines 18a, b probably due to a hydrogenolytic cleavage of the intermediately formed pyrrolidines. The zwitterionic products were obtained in high purity simply by precipitation with Et2O.
- Publication
Helvetica Chimica Acta, 2002, Vol 85, Issue 12, p4200
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.200290005