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- Title
Single-dose intra-articular bupivacaine after knee arthroscopic surgery: a meta-analysis of randomized placebo-controlled studies.
- Authors
Wei, Jie; Yang, Hao-bin; Qin, Jia-bi; Kong, Fan-jing; Yang, Tu-bao
- Abstract
Purpose: The purpose of this meta-analysis was to examine the efficacy and safety of single-dose intra-articular bupivacaine in the management of pain after knee arthroscopic surgery. Method: The comprehensive literature search, using MEDLINE, the Cochrane Central Register of Controlled Trials, and Embase databases, was conducted to identify randomized controlled trials that used single-dose intra-articular bupivacaine for postoperative pain. The relative risk (RR), weighted mean difference (WMD), and their corresponding 95 % confidence intervals (CIs) were calculated using RevMan statistical software. Result: Twenty-three studies ( n = 1287) were included (647 subjects in bupivacaine group and 640 subjects in the control group). Statistically significant differences were observed in the VAS values (WMD −1.1; 95 % CI −1.7 to −0.5), number of patients requiring supplementary analgesia (RR 0.83; 95 % CI 0.74-0.94), and time to first analgesic request (WMD 129.3; 95 % CI 15.4-243.1) among the bupivacaine group when compared to the control group. However, short-term side effects had no significant difference between these two groups (RR 0.73; 95 % CI 0.44-1.24). Conclusions: On the basis of the currently available literature, single-dose intra-articular bupivacaine was shown to be significantly better than placebo at relieving pain after knee arthroscopic surgery. More high-quality randomized controlled trials with long follow-up are highly required for examining the safety of single-dose intra-articular bupivacaine. Besides, routine use of single-dose intra-articular bupivacaine is still an effective way for pain management after knee arthroscopic surgery. Level of evidence: II.
- Subjects
ANALGESICS; INTRA-articular injections; ARTHROSCOPY; POSTOPERATIVE care; RANDOMIZED controlled trials; META-analysis; DRUG efficacy; PLACEBOS
- Publication
Knee Surgery, Sports Traumatology, Arthroscopy, 2014, Vol 22, Issue 7, p1517
- ISSN
0942-2056
- Publication type
Article
- DOI
10.1007/s00167-013-2543-7