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- Title
Hemani et al. reply.
- Authors
Hemani, Gibran; Shakhbazov, Konstantin; McRae, Allan F.; Visscher, Peter M.; Powell, Joseph E.; Westra, Harm-Jan; Franke, Lude; Esko, Tonu; Henders, Anjali K.; Martin, Nicholas G.; Montgomery, Grant W.; Yang, Jian; Gibson, Greg; Metspalu, Andres
- Abstract
Replying to A. R. Wood et al. 514, http://dx.doi.org/10.1038/nature13691 (2014).We thank Wood et al. for their interesting observations and although their proposed mechanism does not explain all our reported results, we acknowledge that alternative mechanisms could be behind the observation of epistatic signals. Although we replicate our results in large, independent samples, 19/30 of our reported interactions (Table 1 in ref. 2), Wood et al. do not replicate in the InCHIANTI data set (n = 450) at a type-I error rate of 0.05/30 = 0.002, including none of our reported cis-trans interactions. Having insufficient data to replicate the discovery interactions makes it problematic to draw firm conclusions on the reported cis-trans effects.
- Subjects
EPISTASIS (Genetics); GENE expression; SINGLE nucleotide polymorphisms; STATISTICAL methods in haplotypes; DNA replication
- Publication
Nature, 2014, Vol 514, Issue 7520, pE5
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature13692