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- Title
Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs.
- Authors
Lange, Charlotte; Malinen, Eirik; Qu, Hong; Johnsrud, Kjersti; Skretting, Arne; Saugstad, Ola; Munkeby, Berit
- Abstract
Purpose: Changes in cerebral glucose metabolism may be an early prognostic indicator of perinatal hypoxic-ischaemic injury. In this study dynamic F-FDG PET was used to evaluate cerebral glucose metabolism in piglets after global perinatal hypoxia and the impact of the resuscitation strategy using room air or hyperoxia. Methods: New-born piglets ( n = 16) underwent 60 min of global hypoxia followed by 30 min of resuscitation with a fraction of inspired oxygen (FiO) of 0.21 or 1.0. Dynamic FDG PET, using a microPET system, was performed at baseline and repeated at the end of resuscitation under stabilized haemodynamic conditions. MRI at 3 T was performed for anatomic correlation. Global and regional cerebral metabolic rates of glucose (CMR) were assessed by Patlak analysis for the two time-points and resuscitation groups. Results: Global hypoxia was found to cause an immediate decrease in cerebral glucose metabolism from a baseline level (mean ± SD) of 21.2 ± 7.9 to 12.6 ± 4.7 μmol/min/100 g ( p <0.01). The basal ganglia, cerebellum and cortex showed the greatest decrease in CMR but no significant differences in global or regional CMR between the resuscitation groups were found. Conclusion: Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMR may indicate early changes of mild cerebral hypoxia-ischaemia. No significant effect of hyperoxic resuscitation on the degree of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of perinatal hypoxic-ischaemic injury where early detection plays an important role in instituting therapy.
- Subjects
POSITRON emission tomography; CEREBRAL anoxia; GLUCOSE metabolism; LABORATORY swine; RESUSCITATION; HYPEROXIA; STATISTICAL correlation; ANIMAL models in research
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2012, Vol 39, Issue 5, p792
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-011-2055-y