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- Title
Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-<italic>ij</italic>]Quinoline-1,2-Diones.
- Authors
Medvedeva, S. M.; Potapov, A. Yu.; Gribkova, I. V.; Katkova, E. V.; Sulimov, V. B.; Shikhaliev, Kh. S.
- Abstract
New factor-Xa inhibitors in a series of pyrrolo[3,2,1-<italic>ij</italic>]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and <italic>H</italic>-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 - 40 μM) were discovered.
- Subjects
PQQ (Biochemistry); ANTICOAGULANTS; MOLECULAR docking; CONDENSATION; AROMATIC amines
- Publication
Pharmaceutical Chemistry Journal, 2018, Vol 51, Issue 11, p975
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-018-1726-4