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- Title
Conjugating Antibodies to Cytotoxic Agents: Getting the Best of Both Worlds?
- Authors
Azvolinsky, Anna
- Abstract
The article discusses the conjugation of antibodies to cytotoxic agents. Topics discussed include the strength of chemotherapy drugs, monoclonal antibodies, and antibody-drug conjugate (ADC). Also mentioned are the approval by the U.S. Food and Drug Administration (FDA) of ADCs, toolboxes being built by drug companies and academic researchers, and cell surface target.
- Subjects
IMMUNOGLOBULINS; ANTINEOPLASTIC agents; CANCER chemotherapy; DRUGS; UNITED States. Food &; Drug Administration; CELL membranes
- Publication
JNCI: Journal of the National Cancer Institute, 2013, Vol 105, Issue 23, p1765
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djt354