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- Title
Immune system dysfunction in broiler chickens experimentally inoculated with fowl adenovirus serotype-4 associated with inclusion body hepatitis hydropericardium syndrome.
- Authors
Hussain, IftIkhar; Mahmood, Muhammad Shahid; Arshad, Muhammad Imran; Akhtar, Masood; Mahmood, Fazal; Rafique, Azhar
- Abstract
Inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) in broilers is caused by an adenovirus, here referred to as inclusion body hepatitis-hydropericardium syndrome virus (IBH-HPSV). This study describes the immune status of broiler chickens experimentally inoculated with an isolate of fowl adenovirus-4 serotype-1, involved in IBH-HPS in various trials. When compared with the unchallenged controls, IBH-HPSV-inoculated broilers had significantly higher atrophy of the bursa of Fabricius (BF) by up to 2-fold, as well as of the thymus (up to 9-fold) and spleen (up to 1.5-fold) (P < 0.05), with up to 60% mortality. Upon challenge with sheep red blood cells (SRBCs), IBH-HPSV-inoculated birds had from 2- to 3-log lower anti-SRBC antibody titers than the control. Response to phytohemagglutinin-P (PHA-P) was significantly reduced in IBH-HPSV-inoculated birds (P < 0.05) as compared to the control. Results of the studies revealed that the immune status of broilers is compromised significantly during IBHHPSV infection in terms of lymphoid organ integrity, humoral, and cell-mediated immune responses, respectively. These findings suggest that immune dysfunction could be a contributing factor in the increased mortality of birds affected by IBH-HPS, which renders the birds immunosuppressed for the rest of their lives.
- Subjects
IMMUNOLOGIC diseases; BROILER chicken diseases; ADENOVIRUSES; SEROTYPES; HEPATITIS; IMMUNE response; ERYTHROCYTES; PHYTOHEMAGGLUTININS
- Publication
Turkish Journal of Veterinary & Animal Sciences, 2012, Vol 36, Issue 3, p223
- ISSN
1300-0128
- Publication type
Article
- DOI
10.3906/vet-0807-21