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- Title
Increased Expression of the Receptor for Advanced Glycation End-Products (RAGE) Is Associated with Advanced Breast Cancer Stage.
- Authors
Nankali, Maryam; Karimi, Jamshid; Goodarzi, Mohammad T.; Saidijam, Massoud; Khodadadi, Iraj; Emami Razavi, Amir N.; Rahimi, Farzaneh
- Abstract
Background: The receptor for advanced glycation endproducts (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. Methods: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. Results: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). Conclusions: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression.
- Publication
Oncology Research & Treatment, 2016, Vol 39, Issue 10, p622
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000449326