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- Title
N-Arylation of 1,2,4- and 1,3,4-Oxadiazolones under Activated Aromatic Nucleophilic Substitution Conditions.
- Authors
Konstantinova, A. S.; Shetnev, A. A.; Volobueva, A. S.; Korsakov, M. K.
- Abstract
The possibilities of N-arylation of 1,2,4-oxadiazol-5(4H)-ones and 1,3,4-oxadiazol-2(3H)-ones with various electron-deficient chloro- and fluorine-substituted nitroarenes under the conditions of the classical activated nucleophilic substitution reaction were studied. A significant difference was found in the reactivity of 1,2,4- and 1,3,4-oxadiazolones in the N-arylation reactions. Methods for the synthesis of N-nitroaryl derivatives of 1,2,4- and 1,3,4-oxadiazolones, providing the target products of sufficient purity in yields of about 65–96%, were developed.
- Subjects
ARYLATION; NUCLEOPHILIC substitution reactions; SUBSTITUTION reactions; NITROAROMATIC compounds
- Publication
Russian Journal of Organic Chemistry, 2023, Vol 59, Issue 11, p1874
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428023110052