We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin D Supplementation and Adherence to World Cancer Research Fund (WCRF) Diet Recommendations for Colorectal Cancer Prevention: A Nested Prospective Cohort Study of a Phase II Randomized Trial.
- Authors
Serrano, Davide; Bellerba, Federica; Johansson, Harriet; Macis, Debora; Aristarco, Valentina; Accornero, Chiara A.; Guerrieri-Gonzaga, Aliana; Trovato, Cristina M.; Zampino, Maria Giulia; Salè, Emanuela Omodeo; Bonanni, Bernardo; Gandini, Sara; Gnagnarella, Patrizia
- Abstract
Vitamin D and a healthy diet, based on World Cancer Research Fund (WCRF) recommendations, are considered key elements for colorectal cancer (CRC) prevention. In a CRC case-control study, we observed that CRC cases were often significantly Vitamin D deficient while subjects following WCRF recommendations significantly decreased their risk of developing CRC. We conducted a randomized phase-II trial (EudraCT number-2015-000467-14) where 74 CRC patients showed differences in response to Vitamin D supplementation, 2000 IU in average per day, according to gender and microbiota. The aim of this nested study is to correlate Vitamin D (supplementation, serum level and receptor polymorphisms), circulating biomarkers, and events (polyp/adenoma, CRC relapse and other cancers) in concomitant to WCRF recommendation adherence. Vitamin D supplementation did not modulate circulating biomarkers or follow-up events. FokI and TaqI VDR were associated with 25-hydroxyvitamin D (25OHD) levels. Patients following the WCRF recommendations had significantly lower leptin, significantly lower IL-6 (only in females), and significantly lower risk of events (HR = 0.41, 95%CI: 0.18–0.92; p = 0.03; median follow-up 2.6 years). Interestingly, no WCRF adherents had significantly more events if they were in the placebo (p < 0.0001), whereas no influence of WCRF was observed in the Vitamin D arm. While one-year Vitamin D supplementation might be too short to show significant preventive activity, a healthy diet and lifestyle should be the first step for preventive programs.
- Subjects
VITAMIN D; DIETARY supplements; COLORECTAL cancer; CANCER prevention; CANCER research
- Publication
Biomedicines, 2023, Vol 11, Issue 6, p1766
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11061766