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- Title
Time-Domain T-Wave Alternans is Strongly Associated with a History of Ventricular Fibrillation in Patients with Brugada Syndrome.
- Authors
UCHIMURA‐MAKITA, YUKO; NAKANO, YUKIKO; TOKUYAMA, TAKEHITO; FUJIWARA, MAI; WATANABE, YOSHIKAZU; SAIRAKU, AKINORI; KAWAZOE, HIROSHI; MATSUMURA, HIROYA; ODA, NOZOMU; IKANAGA, HIROKI; MOTODA, CHIKAAKI; KAJIHARA, KENTA; ODA, NOBORU; VERRIER, RICHARD L.; KIHARA, YASUKI
- Abstract
Time-Domain T-Wave Alternans and Brugada Syndrome Aims T-wave alternans (TWA) is an indicator of vulnerability to ventricular arrhythmias and is useful for predicting sudden cardiac death (SCD) in patients with various structural heart diseases. We evaluated whether high levels of time-domain TWA on ambulatory ECG (AECG) are associated with a history of ventricular fibrillation (VF) in Brugada syndrome (BrS) patients. Methods and Results We examined the associations among VF history, family history of SCD, spontaneous type 1 electrocardiogram (ECG), late potentials, VF induction by programmed electrical stimulation, and TWA in 45 BrS patients (44 males; mean age, 45 ± 15 years). TWA analyzed from 24-h AECG recordings using the modified moving average method was positive in 13 of 43 patients (30%). Patients with a history of VF had a significantly higher incidence of a positive TWA test (82% vs. 13%; P < 0.001) and spontaneous type 1 ECG (92% vs. 38%; P = 0.007) than those without VF history. Multivariate analysis indicated that positive TWA (OR 7.217; 95% CI 2.503-35.504; P = 0.002) and spontaneous type 1 ECG (OR 5.530; 95% CI 1.651-34.337; P = 0.020) were closely associated with VF history. Spontaneous type 1 ECG had high sensitivity (92%) but low specificity (63%). Positive TWA was a reliable marker with high sensitivity and specificity (82% and 88%, respectively). Conclusion Elevated time-domain TWA on AECG confirms arrhythmia risk in symptomatic BrS patients without the need for provocative stimuli.
- Subjects
JAPAN; VENTRICULAR fibrillation; RISK assessment; ACADEMIC medical centers; AMBULATORY electrocardiography; ANALYSIS of variance; CHI-squared test; CONFIDENCE intervals; T-test (Statistics); TIME; MULTIPLE regression analysis; BRUGADA syndrome; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; ODDS ratio; DISEASE complications; DISEASE risk factors
- Publication
Journal of Cardiovascular Electrophysiology, 2014, Vol 25, Issue 9, p1021
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1111/jce.12441