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- Title
A Prospective Randomized Single-Center Study on the Risk of Asymptomatic Cerebral Lesions Comparing Irrigated Radiofrequency Current Ablation with the Cryoballoon and the Laser Balloon.
- Authors
SCHMIDT, BORIS; GUNAWARDENE, MELANIE; KRIEG, DETLEF; BORDIGNON, STEFANO; FÜRNKRANZ, ALEXANDER; KULIKOGLU, MEHMET; HERRMANN, WILFRIED; CHUN, K.R. JULIAN
- Abstract
Asymptomatic Cerebral Lesions in AF Ablation Background Asymptomatic cerebral lesions (ACL) may occur during atrial fibrillation (AF) ablation. We sought to compare the ACL incidence between 3 contemporary technologies: (1) irrigated radiofrequency current (RFC), (2) the single big cryoballoon (CB), and (3) the endoscopic laser-balloon (LB) in a prospective randomized pilot study. Methods and Results Ninety-nine patients were treated in 3 groups. Diffusion weighted MRI was acquired pre- (n = 20) and 24-48 h postablation (n = 99). After ablation, new ACL were detected in 22% of patients without significant differences between groups (RFC 8/33; CB 6/33; LB 8/33; P = 0.8). The presence of hypertension was identified as the only independent predictor of ACL by univariate regression analysis. During LB ablation, more ablation lesions (140 ± 19 vs 119 ± 18; P = 0.007) were applied during longer procedures (166 ± 36 vs 143 ± 32 min; P = 0.05) in patients with ACL. Univariate analysis revealed that a higher number of ablation lesions predicted ACL (P = 0.02). Conclusion In this prospective, randomized, single-center pilot study, ablation technology did not influence the occurrence of ACL during AF ablation.
- Subjects
ATRIAL fibrillation treatment; CATHETER ablation; ANALYSIS of variance; COLD therapy; FISHER exact test; MEDICAL lasers; LONGITUDINAL method; MAGNETIC resonance imaging; REGRESSION analysis; PILOT projects; RANDOMIZED controlled trials; DATA analysis software; DESCRIPTIVE statistics
- Publication
Journal of Cardiovascular Electrophysiology, 2013, Vol 24, Issue 8, p869
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1111/jce.12151