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- Title
Synthesis and Anticoagulant Activity of New Ethylidene and Spiro Derivatives of Pyrrolo[3,2,1-ij]quinolin-2-ones.
- Authors
Novichikhina, N. P.; Skoptsova, A. A.; Shestakov, A. S.; Potapov, A. Yu.; Kosheleva, E. A.; Kozaderov, O. A.; Ledenyova, I. V.; Podoplelova, N. A.; Panteleev, M. A.; Shikhaliev, Kh. S.
- Abstract
The reaction of pyrrolo[3,2,1-ij]quinoline-1,2-diones with methyl (het)aryl ketones gave the corresponding 1-(het)arylmethylidenepyrroloquinolin-2-ones, and 1,3-dipolar cycloaddition of the latter to azomethine ylide generated from sarcosine and paraformaldehyde afforded 4-acyl-1,4′,4′,6′-tetramethylspiro[pyrrolidine-3,1′-pyrrolo[3,2,1-ij]quinolin]-2′(4′H)-ones. The synthesized compounds were evaluated for inhibitory activity against blood coagulation factors Xa and XIa.
- Subjects
BLOOD coagulation factor X; ANTICOAGULANTS; ISOXAZOLIDINES
- Publication
Russian Journal of Organic Chemistry, 2020, Vol 56, Issue 9, p1550
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428020090080