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- Title
Preparation of enantiomeric pure (−)-(3 R,4 S)-1-benzyl-3,4-epoxypiperidine and enriched (−)-( R)-1-Benzyl-3-hydroxy-1,2,3,6-tetrahydropyridine by kinetic separation of (±)-1-benzyl-3,4-epoxypiperidine under the action of chiral lithium amides
- Authors
Grishina, G. V.; Veselov, I. S.; Davankov, V. A.; Il'in, M. M.; Zefirov, N. S.
- Abstract
Enantiomeric pure (−)-(3 R,4 S)-1-benzyl-3,4-epoxypiperidine and (−)-( R)-1-benzyl-3-hydroxy-1,2,3,6-tetrahydropyridine with enantiomeric excess 61.9% were obtained by kinetic separation of (±)-1-benzyl-3,4-epoxypiperidine under the action of lithium salt (+)-( S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine. The sterical direction of the kinetic separation of (±)-1-benzyl-3,4-epoxypiperidine and absolute configurations of the target products were established.
- Subjects
ENANTIOMERS; PIPERIDINE; PYRROLIDINE; HYDROXYLATION; CHEMICAL reactions; ORGANIC chemistry
- Publication
Russian Journal of Organic Chemistry, 2008, Vol 44, Issue 2, p282
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428008020164