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- Title
An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate.
- Authors
Chapala, Vijaya Lakshmi; Katari, Naresh Kumar; Malavattu, Giri Prasad; Kerru, Nagaraju; Reddy, Pedavenkatagari Narayana; Marisetti, Vishnu Murthy
- Abstract
Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphenylprolinol with NaBH4. This target chiral synthesis requires simple starting materials and inexpensive catalysts.
- Subjects
AMINES; HEPATITIS C virus
- Publication
Russian Journal of General Chemistry, 2021, Vol 91, Issue 5, p932
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S107036322105025X