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- Title
Asthma and insulin resistance in children.
- Authors
Arshi, Mandana; Cardinal, John; Hill, Rebecca J.; Davies, Peter S.W.; Wainwright, Claire
- Abstract
Background and objective: Increased BMI is a risk factor for asthma in children and may be related to adipokines. Adipokines affect insulin-stimulated glucose uptake in vitro but, to date there is little evidence for such a role in vivo. We explored relationships between obesity and allergic asthma in children. Methods: Twenty-one allergic asthmatics (AA) and 10 non-allergic healthy controls, aged 6–17.9 years were studied. AA group included children with a positive mannitol challenge test, >25 ppb of exhaled nitric oxide and a positive skin prick test. BMI z-scores were calculated. Blood levels of insulin, glucose, leptin, resistin, tumour necrosis factor-α, IL-4, IL-5 and IL-6 were measured. Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA). Results: There was no significant difference in BMI z-scores between AA and healthy controls (mean: 0.01 vs −0.10). However, significant differences were found in the blood levels of IL-6 ( P = 0.05), IL-4 ( P = 0.04), IL-5 ( P = 0.01) and leptin ( P = 0.02). IR was only found in the AA group (42.85%). Homeostasis model assessment insulin resistance (HOMA-IR) was significantly related to IL-6 ( r = 0.44, P = 0.05) and tumour necrosis factor-α ( r = −0.45, P = 0.05). Conclusions: IR was observed in AA. Our findings are suggestive of a complex interaction between the inflammatory state and adiposity, allergy and asthma.
- Subjects
ASTHMA in children; CHILDHOOD obesity; LIPOTROPIN; BODY mass index; INSULIN resistance; HOMEOSTASIS
- Publication
Respirology, 2010, Vol 15, Issue 5, p779
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/j.1440-1843.2010.01767.x