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- Title
Multicomponent Reactions of Aldo-X Bifunctional Reagent α-Oxoketene Dithioacetals and Indoles or Amines: Divergent Synthesis of Dihydrocoumarins, Quinolines, Furans, and Pyrroles.
- Authors
Liu, Changhui; Zhou, Li; Jiang, Dan; Gu, Yanlong
- Abstract
Six multicomponent reactions were developed by using aldo-X reagents and α-oxoketene dithioacetals with indoles or amines as substrates, which can be used to prepare many heterocycles, such as dihydrocoumarins, quinolines, furans and pyrroles, in a straightforward way. A combination of two bifunctional aldo-X reagents and α-oxoketene dithioacetals is the key to make the discovery of these multicomponent reactions possible because these reagents have a minimum of two reactive sites, which enable different substrates to be assembled together in various manners.
- Subjects
HETEROCYCLIC compounds; INDOLE compounds; FURANS
- Publication
Asian Journal of Organic Chemistry, 2016, Vol 5, Issue 3, p367
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201500497