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- Title
Challenges in Drug and Hymenoptera Venom Hypersensitivity Diagnosis and Management in Mastocytosis.
- Authors
Giannetti, Matthew P.; Nicoloro-SantaBarbara, Jennifer; Godwin, Grace; Middlesworth, Julia; Espeland, Andrew; Douvas, Julia L.; Castells, Mariana C.
- Abstract
Mastocytosis is a myeloproliferative neoplasm characterized by abnormal proliferation and activation of clonal mast cells typically bearing the KITD816V mutation. Symptoms manifest due to the release of bioactive mediators and the tissue infiltration by neoplastic mast cells. Mast cell activation symptoms include flushing, pruritus, urticaria, abdominal cramping, diarrhea, wheezing, neuropsychiatric symptoms, and anaphylaxis. Up to 50% of patients with mastocytosis report a history of provoked and unprovoked anaphylaxis, with Hymenoptera venom and drugs the most common culprits. NSAIDs, antibiotics, vaccines, perioperative medications, and radiocontrast media are often empirically avoided without evidence of reactions, depriving patients of needed medications and placing them at risk for unfavorable outcomes. The purpose of this review is to highlight the most common agents responsible for adverse drug reactions in patients with mastocytosis, with a review of current epidemiology, diagnosis, and management of drug hypersensitivity and Hymenoptera venom allergy.
- Subjects
MAST cell disease; VENOM hypersensitivity; DRUG side effects; DIAGNOSIS; MAST cells; HYMENOPTERA
- Publication
Diagnostics (2075-4418), 2024, Vol 14, Issue 2, p123
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics14020123