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- Title
Treatment of canine Alopecia X with trilostane.
- Authors
Cerundolo, Rosario; Lloyd, David H.; Persechino, Angelo; Evans, Helen; Cauvin, Andria
- Abstract
Sixteen Pomeranians and eight miniature poodles presenting with clinical signs of alopecia X, elevated blood concentrations of 17-hydroxyprogesterone post stimulation with adrenocorticotropic hormone and increased urinary cortisol/creatinine ratios were treated with trilostane, a competitive inhibitor of 3β-hydroxysteroid dehydrogenase. Trilostane was given once or twice daily at a mean dose of 10.85 mg kg−1 day−1.Adrenal function was evaluated with a follow-up of 28 months in the Pomeranians and 33 months in the miniature poodles. Treatment with trilostane led to complete hair re-growth in 85% of the Pomeranians and in all of the miniature poodles within 4 to 8 weeks. No adverse events attributed to treatment with trilostane were recognized. The hair re-growth might have been the result of a down-regulation of adrenal steroids and/or of the noncompetitive inhibition of the oestrogen receptors at the hair follicle level.
- Subjects
DOG diseases; BALDNESS; POODLES; ADRENOCORTICAL hormones; HAIR follicles; VETERINARY dermatology
- Publication
Veterinary Dermatology, 2004, Vol 15, Issue 5, p285
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2004.00403.x