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- Title
Pharmacokinetics of xanthohumol in rats of both sexes after oral and intravenous administration of pure xanthohumol and prenylflavonoid extract.
- Authors
Nowak, Beata; Poźniak, Błażej; Popłoński, Jarosław; Bobak, Łukasz; Matuszewska, Agnieszka; Kwiatkowska, Joanna; Dziewiszek, Wojciech; Huszcza, Ewa; Szeląg, Adam
- Abstract
Background. Female inflorescences of hops (Humulus lupulus L.) are wildly used in the brewing industry. Hops have been also used for ages in folk medicine. Xanthohumol (XN) is a most abundant prenylated flavonoid present in hops. Objectives. To determine pharmacokinetic parameters and bioavailability of pure XN and XN given in prenylflavonoid extract obtained from spent hops (HOP). Material and methods. Fifty-six Wistar rats (28 females and 28 males) were administered with XN or HOP. Xanthohumol was administered either intravenously (iv.) (10 mg/kg) or orally (per os (p.o.)) (40, 100 and 200 mg/kg). Extract obtained from spent hops was administered p.o. and its doses were based on XN content (doses were equivalent to XN dose of 40, 100 and 200 mg/kg, respectively). After administration of XN or HOP serum, XN concentration was measured at different time points (0, 0.25, 0.5, 1, 2, 4, 6, 12, 24, 48, 72, and 96 h). Non-compartmental analysis was used to assess the pharmacokinetics (PK) of XN in rats. Results. The XN PK in rats after intravenous administration is characterized by extensive distribution followed by delayed elimination from the body. Enterohepatic recirculation is likely to play a role in XN PK. Some fraction of the orally administered XN reaches central compartment rapidly; however, the overall absorption is very limited and probably saturable. The formulation-dependent factors also play an important role in the bioavailability of the drug. Although the CMAX concentration was higher in female rats receiving XN orally comparing to males, the other pharmacokinetic parameters were unaffected by the rats' sex. Conclusions. The same doses of XN may be administered to male and female subjects, as its pharmacokinetics is not affected by sex.
- Subjects
INTRAVENOUS therapy; HOPS; PHARMACOKINETICS; DRUG bioavailability
- Publication
Advances in Clinical & Experimental Medicine, 2020, Vol 29, Issue 9, p1101
- ISSN
1899-5276
- Publication type
Article
- DOI
10.17219/acem/126293