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- Title
An evaluation of the effect on lower extremity fracture healing of collagen-based fusion material containing 2 different calcium phosphate salts: An experimental rat model.
- Authors
Aksekili, Atıf Mehmet Erol; Polat, Yusuf; Yüksel, Kaan; Asiltürk, Mehmet; Uğurlu, Mahmut; Kara, Halil; Önder, Evrim Öztürk; Tosun, Nihat
- Abstract
Background. Collagen-based synthetic bone grafts which contain tricalcium phosphate (TCP) and hydroxyapatite (HA), and collagen-based synthetic bone grafts containing only TCP have some advantages compared to autografts. Therefore, these grafts are frequently used to fill bone defects and pseudoarthrosis. Objectives. The aim of this study was to evaluate and compare the clinical, radiological and histopathological effects of TCP-HA and TCP alone + Type-1 collagen in healing lower extremity fractures in a pseudoarthrosis model in rat femurs. Material and methods. A total of 36 female Wistar rats were randomly separated into 4 groups. Group 1 (n = 10) was the control group. A femur pseudoarthrosis model was created in Groups 2, 3 and 4. On the 90th day after the 1st surgery in Group 2 (n = 10), TCP-HA + Type-1 collagen was applied, in Group 3 (n = 10), TCP alone + type-1 collagen was applied, and in Group 4 (n = 6, the placebo group), saline solution was applied. Fixation was performed with an intramedullar pin. After 60 days and clinical and radiological scoring, all animals were sacrificed and a histopathological evaluation of the pseudoarthrosis areas was conducted. Results. In all the clinical, radiological and histopathological measurements used in the evaluations of the differences between the groups, a higher rate of union was determined in Group 2 (TCP-HA). No significant difference was determined between Group 3 and Group 4 in terms of union rates. Conclusions. The clinical, radiological and histopathological results of this study showed that TCP alone was less effective than TCP-HA in the union of a femur pseudoarthrosis model in rats. The reason for this difference was considered to be hydroxyapatite (HA).
- Subjects
LEG fractures; BONE grafting; COLLAGEN; HYDROXYAPATITE; PSEUDARTHROSIS; LABORATORY rats
- Publication
Advances in Clinical & Experimental Medicine, 2018, Vol 27, Issue 9, p1295
- ISSN
1899-5276
- Publication type
Article
- DOI
10.17219/acem/90766