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- Title
Editorial: CD24 in the regulation of cellular development and disease.
- Authors
Christian, Sherri L.; Cambridge, Geraldine
- Abstract
This article is an editorial that explores the role of CD24 in cellular development and disease. CD24 is a molecule found on various cells, including immune cells, and its glycosylation gives it diverse biological functions. It is involved in B cell development and is expressed at different stages of maturation. CD24 expression is also associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and is increased in individuals with this condition. Additionally, CD24 is expressed in solid tumors and is linked to increased metastatic potential. The article discusses the use of CD24 as a target for immunotherapy and its role in immune evasion. It highlights two review articles that explore the interactions between CD24 and Siglecs, as well as the association of CD24 with ovarian cancer. Original research articles are also mentioned, which demonstrate the contribution of CD24 expression on dendritic cells to T cell priming and the association of CD24 with B cell metabolism in ME/CFS patients. The document emphasizes the potential role of CD24 in regulating immune and metabolic processes in B cells, and the altered CD24 expression in B cells from ME/CFS patients. It also discusses the diverse functions of CD24 in immune and innate cell interactions with tumor cells and its contribution to T cell priming. The authors of the article declare no conflicts of interest, and the claims expressed in the article are solely those of the authors.
- Subjects
B cell receptors; BONE marrow cells; IMMUNOLOGIC memory; CELL receptors; MYELOID cells; FRACTALKINE
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1374701