We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells.
- Authors
Sugiyanto, Zaenal; Yohan, Benediktus; Hadisaputro, Soeharyo; Dharmana, Edi; Suharti, Catharina; Winarto; Djamiatun, Kis; Rahmi, Fifin L.; Sasmono, R. Tedjo
- Abstract
Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.
- Subjects
VIRAL replication; BLOOD cells; DENGUE viruses; CYTOKINES; DIETARY supplements; DENGUE
- Publication
Natural Products & Bioprospecting, 2019, Vol 9, Issue 5, p345
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-019-00218-z