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- Title
Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects.
- Authors
Rodrigues, Daniela Oliveira Werneck; Diniz, Roberta Wolp; Dentz, Leonardo Cunha; de Albuquerque Costa, Monica; Lopes, Roberto Heleno; Suassuna, Lucas Fernandes; Cintra, Jane Rocha Duarte; Domenge, Christian
- Abstract
Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis, usually self-limited and presenting with massive, painless, bilateral cervical lymphadenopathy, with or without constitutional symptoms. Extranodal disease is frequently present, and may happen in the absence of lymph node involvement, symptomatology and differential diagnosis will depend on the site affected and fatal cases may occur. The authors present two cases of Rosai-Dorfman disease (RDD), diagnosed through immunohistochemistry, with different progressions, one with complete remission and one culminating in death, highlighting the variety of presentations and the diagnostic difficulty. RDD is a rare condition with clinical presentations similar to several diseases, and should be considered in the differential diagnosis of lymphadenopathy with extranodal lesions.
- Subjects
NON-langerhans-cell histiocytosis; LYMPHADENITIS; SYMPTOMS; ERDHEIM-Chester disease; HISTIOCYTOSIS; DIFFERENTIAL diagnosis; LYMPH nodes
- Publication
Journal of Blood Medicine, 2024, Vol 15, p123
- ISSN
1179-2736
- Publication type
Case Study
- DOI
10.2147/JBM.S436720