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- Title
VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection.
- Authors
Tyagi, Shaifali; Sadhu, Srikanth; Sharma, Taruna; Paul, Abhijit; Pandey, Manitosh; Nain, Vaibhav Kumar; Rathore, Deepak Kumar; Chatterjee, Samrat; Awasthi, Amit; Pandey, Amit Kumar
- Abstract
Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol-induced activation of VapC12 ribonuclease is critical for disease persistence in TB. In this study, we observed that relative to the wild type, mice infected with DvapC12 induced a pro-inflammatory response, had a higher pathogen load, and responded better to the anti-TB treatment. In a high-dose infection model, all the mice infected with DvapC12 succumbed early to the disease. Finally, we reported that the above phenotype of DvapC12 was dependent on the presence of the TLR4 receptor. Overall, the data suggests that failure of a timely resolution of the early inflammation by the DvapC12 infected mice led to hyperinflammation, altered T-cell response and high bacterial load. In conclusion, our findings suggest the role of the VapC12 toxin in modulating the innate immune response of the host in ways that favor the long-term survival of the pathogen inside the host.
- Subjects
MYCOBACTERIAL diseases; MYCOBACTERIUM tuberculosis; RIBONUCLEASES; MULTIDRUG-resistant tuberculosis; IMMUNE response
- Publication
Frontiers in Immunology, 2024, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2024.1302163